![]() Furthermore, our biochemical studies provide evidence that comfrey inhibits NF-κB signaling at two stages: it dampens not only the activation of IKK1/2 and the subsequent IκBα degradation, but also interferes with NF-κB p65 nucleo-cytoplasmatic shuttling and transactivation. Both preparations inhibit the activation of NF-κB, a transcription factor of central importance for the expression of these and other pro-inflammatory genes. ![]() The extract, and especially its mucilage-depleted fraction, impair the interleukin-1 (IL-1) induced expression of pro-inflammatory markers including E-selectin, VCAM1, ICAM1, and COX-2. Here, we show that a hydroalcoholic extract of comfrey root impairs the development of a pro-inflammatory scenario in primary human endothelial cells in a dose-dependent manner. However, the molecular basis of its action remained elusive. Today, its topical use is based on its analgesic and anti-inflammatory effects, which have been substantiated by modern clinical trials. Symphytum officinale, commonly known as comfrey, constitutes a traditional medicinal plant with a long-standing therapeutic history, and preparations thereof have been widely used for the treatment of painful muscle and joint complaints, wound and bone healing, and inflammation. 3Dipartimento di Farmacia, Università degli Studi di Salerno, Salerno, Italy.2R&D, Procter & Gamble Health, Darmstadt, Germany. ![]() 1Department of Vascular Biology, Medical University of Vienna, Vienna, Austria. ![]() Holper-Schichl 4* † and Rainer de Martin 1* † Jacqueline Seigner 1, Marc Junker-Samek 2, Alberto Plaza 2, Gilda D‘Urso 3, Milena Masullo 3, Sonia Piacente 3, Yvonne M. ![]()
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